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In mice with colon adenocarcinoma C-26 application, BPC 157 prolonged survival, counteracted the muscle wasting, counteracted increase of the pro-cachectic and pro-inflammatory mediators, and changes in the expression of forkhead transcription factor O subfamily member 3a (FoxO3a), phospho-protein kinase B (p-AKT), phosphorylation of mammalian target of rapamycin (p-mTOR), and glycogen synthase kinase 3beta (P-GSK-3b) (8)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Peng C., Stewart A.G., Woodman O.L., Ritchie R.H., Qin C.X